N01-HV-28186 (PI Williams)
9/30/02 - 9/29/09
NIH/NHBLI
Yale/NHLBI Proteomics Center Contract
Role: Informatics co-director

The overall grant is funding for a proteomics center at Yale. This center is focused on developing and implementing MS-based analysis of protein expression and protein phosphorylation at the "genome" level. The Gerstein lab contribution, entitled "Functional and Interrelative Proteomics," is to develop approaches for globally comparing and correlating protein abundance and mRNA levels and relating this to complexes.

Progress Report Feb. 2007 [doc] [html]
Extract from Mar. 2007 NewsSpot [pdf]


URL: http://info.med.yale.edu/nhlbi-proteomics
Articles funded by this grant:
The role of disorder in interaction networks: a structural analysis.
PM Kim, A Sboner, Y Xia, M Gerstein (2008). Mol Syst Biol 4: 179.

PARE: a tool for comparing protein abundance and mRNA expression data.
EZ Yu, AE Burba, M Gerstein (2007). BMC Bioinformatics 8: 309.

Relating three-dimensional structures to protein networks provides evolutionary insights.
PM Kim, LJ Lu, Y Xia, MB Gerstein (2006). Science 314: 1938-41.

Helix Interaction Tool (HIT): a web-based tool for analysis of helix-helix interactions in proteins.
AE Burba, U Lehnert, EZ Yu, M Gerstein (2006). Bioinformatics 22: 2735-8.

Comparing protein abundance and mRNA expression levels on a genomic scale.
D Greenbaum, C Colangelo, K Williams, M Gerstein (2003). Genome Biol 4: 117.

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