Summary of Gerstein Lab Research in 2015

Highlights for 2015 include a number of technical computational biology papers, discussing such things as structural variant breakpoint analysis, regulatory network characterization in terms of logical circuits, and the identification of recurrent cancer variants.

We also participated in some major consortium papers (1000G, PsychENCODE, and TCGA Prostate & Kidney) and had some popular-interest pieces (eg a SF Chronicle op-ed on website egulation). There were a few important lectures (eg keynote at Genome Informatics '15).

Finally, we received new grants such as the renewal of the Yale CMG sequencing center.

Knowledge Based Factorized High Order Sparse Learning Models
S Purushotham, MR Min, CJ Kuo, M Gerstein (2015). NIPS Workshop on Machine Learning in Computational Biology.

The Molecular Taxonomy of Primary Prostate Cancer.
Cancer Genome Atlas Research Network (2015). Cell 163: 1011-25.

Reads meet rotamers: structural biology in the age of deep sequencing.
A Sethi, D Clarke, J Chen, S Kumar, TR Galeev, L Regan, M Gerstein (2015). Curr Opin Struct Biol 35: 125-34.

The PsychENCODE project.
PsychENCODE Consortium, S Akbarian, C Liu, JA Knowles, FM Vaccarino, PJ Farnham, GE Crawford, AE Jaffe, D Pinto, S Dracheva, DH Geschwind, J Mill, AC Nairn, A Abyzov, S Pochareddy, S Prabhakar, S Weissman, PF Sullivan, MW State, Z Weng, MA Peters, KP White, MB Gerstein, A Amiri, C Armoskus, AE Ashley-Koch, T Bae, A Beckel-Mitchener, BP Berman, GA Coetzee, G Coppola, N Francoeur, M Fromer, R Gao, K Grennan, J Herstein, DH Kavanagh, NA Ivanov, Y Jiang, RR Kitchen, A Kozlenkov, M Kundakovic, M Li, Z Li, S Liu, LM Mangravite, E Mattei, E Markenscoff-Papadimitriou, FC Navarro, N North, L Omberg, D Panchision, N Parikshak, J Poschmann, AJ Price, M Purcaro, TE Reddy, P Roussos, S Schreiner, S Scuderi, R Sebra, M Shibata, AW Shieh, M Skarica, W Sun, V Swarup, A Thomas, J Tsuji, H van Bakel, D Wang, Y Wang, K Wang, DM Werling, AJ Willsey, H Witt, H Won, CC Wong, GA Wray, EY Wu, X Xu, L Yao, G Senthil, T Lehner, P Sklar, N Sestan (2015). Nat Neurosci 18: 1707-12.

Illuminating the Genome's Dark Matter
D Greenbaum, M Gerstein (2015). Cell 163:1047-1048.

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
Cancer Genome Atlas Research Network, WM Linehan, PT Spellman, CJ Ricketts, CJ Creighton, SS Fei, C Davis, DA Wheeler, BA Murray, L Schmidt, CD Vocke, M Peto, AA Al Mamun, E Shinbrot, A Sethi, S Brooks, WK Rathmell, AN Brooks, KA Hoadley, AG Robertson, D Brooks, R Bowlby, S Sadeghi, H Shen, DJ Weisenberger, M Bootwalla, SB Baylin, PW Laird, AD Cherniack, G Saksena, S Haake, J Li, H Liang, Y Lu, GB Mills, R Akbani, MD Leiserson, BJ Raphael, P Anur, D Bottaro, L Albiges, N Barnabas, TK Choueiri, B Czerniak, AK Godwin, AA Hakimi, TH Ho, J Hsieh, M Ittmann, WY Kim, B Krishnan, MJ Merino, KR Mills Shaw, VE Reuter, E Reznik, CS Shelley, B Shuch, S Signoretti, R Srinivasan, P Tamboli, G Thomas, S Tickoo, K Burnett, D Crain, J Gardner, K Lau, D Mallery, S Morris, JD Paulauskis, RJ Penny, C Shelton, WT Shelton, M Sherman, E Thompson, P Yena, MT Avedon, J Bowen, JM Gastier-Foster, M Gerken, KM Leraas, TM Lichtenberg, NC Ramirez, T Santos, L Wise, E Zmuda, JA Demchok, I Felau, CM Hutter, M Sheth, HJ Sofia, R Tarnuzzer, Z Wang, L Yang, JC Zenklusen, J Zhang, B Ayala, J Baboud, S Chudamani, J Liu, L Lolla, R Naresh, T Pihl, Q Sun, Y Wan, Y Wu, A Ally, M Balasundaram, S Balu, R Beroukhim, T Bodenheimer, C Buhay, YS Butterfield, R Carlsen, SL Carter, H Chao, E Chuah, A Clarke, KR Covington, M Dahdouli, N Dewal, N Dhalla, HV Doddapaneni, JA Drummond, SB Gabriel, RA Gibbs, R Guin, W Hale, A Hawes, DN Hayes, RA Holt, AP Hoyle, SR Jefferys, SJ Jones, CD Jones, D Kalra, C Kovar, L Lewis, J Li, Y Ma, MA Marra, M Mayo, S Meng, M Meyerson, PA Mieczkowski, RA Moore, D Morton, LE Mose, AJ Mungall, D Muzny, JS Parker, CM Perou, J Roach, JE Schein, SE Schumacher, Y Shi, JV Simons, P Sipahimalani, T Skelly, MG Soloway, C Sougnez, A Tam, D Tan, N Thiessen, U Veluvolu, M Wang, MD Wilkerson, T Wong, J Wu, L Xi, J Zhou, J Bedford, F Chen, Y Fu, M Gerstein, D Haussler, K Kasaian, P Lai, S Ling, A Radenbaugh, D Van Den Berg, JN Weinstein, J Zhu, M Albert, I Alexopoulou, JJ Andersen, JT Auman, J Bartlett, S Bastacky, J Bergsten, ML Blute, L Boice, RJ Bollag, J Boyd, E Castle, YB Chen, JC Cheville, E Curley, B Davies, A DeVolk, R Dhir, L Dike, J Eckman, J Engel, J Harr, R Hrebinko, M Huang, L Huelsenbeck-Dill, M Iacocca, B Jacobs, M Lobis, JK Maranchie, S McMeekin, J Myers, J Nelson, J Parfitt, A Parwani, N Petrelli, B Rabeno, S Roy, AL Salner, J Slaton, M Stanton, RH Thompson, L Thorne, K Tucker, PM Weinberger, C Winemiller, LA Zach, R Zuna (2015). N Engl J Med 374: 135-45.

A global reference for human genetic variation.
1000 Genomes Project Consortium, A Auton, LD Brooks, RM Durbin, EP Garrison, HM Kang, JO Korbel, JL Marchini, S McCarthy, GA McVean, GR Abecasis (2015). Nature 526: 68-74.

An integrated map of structural variation in 2,504 human genomes.
PH Sudmant, T Rausch, EJ Gardner, RE Handsaker, A Abyzov, J Huddleston, Y Zhang, K Ye, G Jun, MH Fritz, MK Konkel, A Malhotra, AM Stutz, X Shi, FP Casale, J Chen, F Hormozdiari, G Dayama, K Chen, M Malig, MJP Chaisson, K Walter, S Meiers, S Kashin, E Garrison, A Auton, HYK Lam, XJ Mu, C Alkan, D Antaki, T Bae, E Cerveira, P Chines, Z Chong, L Clarke, E Dal, L Ding, S Emery, X Fan, M Gujral, F Kahveci, JM Kidd, Y Kong, EW Lameijer, S McCarthy, P Flicek, RA Gibbs, G Marth, CE Mason, A Menelaou, DM Muzny, BJ Nelson, A Noor, NF Parrish, M Pendleton, A Quitadamo, B Raeder, EE Schadt, M Romanovitch, A Schlattl, R Sebra, AA Shabalin, A Untergasser, JA Walker, M Wang, F Yu, C Zhang, J Zhang, X Zheng-Bradley, W Zhou, T Zichner, J Sebat, MA Batzer, SA McCarroll, 1000 Genomes Project Consortium, RE Mills, MB Gerstein, A Bashir, O Stegle, SE Devine, C Lee, EE Eichler, JO Korbel (2015). Nature 526: 75-81.

Leveraging long read sequencing from a single individual to provide a comprehensive resource for benchmarking variant calling methods.
JC Mu, P Tootoonchi Afshar, M Mohiyuddin, X Chen, J Li, N Bani Asadi, MB Gerstein, WH Wong, HY Lam (2015). Sci Rep 5: 14493.

An ensemble approach to accurately detect somatic mutations using SomaticSeq.
LT Fang, PT Afshar, A Chhibber, M Mohiyuddin, Y Fan, JC Mu, G Gibeling, S Barr, NB Asadi, MB Gerstein, DC Koboldt, W Wang, WH Wong, HY Lam (2015). Genome Biol 16: 197.

Tracking Distinct RNA Populations Using Efficient and Reversible Covalent Chemistry.
EE Duffy, M Rutenberg-Schoenberg, CD Stark, RR Kitchen, MB Gerstein, MD Simon (2015). Mol Cell 59: 858-66.

LARVA: an integrative framework for large-scale analysis of recurrent variants in noncoding annotations.
L Lochovsky, J Zhang, Y Fu, E Khurana, M Gerstein (2015). Nucleic Acids Res 43: 8123-34.

High-order neural networks and kernel methods for peptide-MHC binding prediction.
PP Kuksa, MR Min, R Dugar, M Gerstein (2015). Bioinformatics 31: 3600-7.

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders.
J Mariani, G Coppola, P Zhang, A Abyzov, L Provini, L Tomasini, M Amenduni, A Szekely, D Palejev, M Wilson, M Gerstein, EL Grigorenko, K Chawarska, KA Pelphrey, JR Howe, FM Vaccarino (2015). Cell 162: 375-390.

Analysis of deletion breakpoints from 1,092 humans reveals details of mutation mechanisms.
A Abyzov, S Li, DR Kim, M Mohiyuddin, AM Stutz, NF Parrish, XJ Mu, W Clark, K Chen, M Hurles, JO Korbel, HY Lam, C Lee, MB Gerstein (2015). Nat Commun 6: 7256.

The computer connection
D Greenbaum, M Gerstein (2015). Science 347: 956.

MetaSV: an accurate and integrative structural-variant caller for next generation sequencing.
M Mohiyuddin, JC Mu, J Li, N Bani Asadi, MB Gerstein, A Abyzov, WH Wong, HY Lam (2015). Bioinformatics 31: 2741-4.

Loregic: a method to characterize the cooperative logic of regulatory factors.
D Wang, KK Yan, C Sisu, C Cheng, J Rozowsky, W Meyerson, MB Gerstein (2015). PLoS Comput Biol 11: e1004132.

An approach for determining and measuring network hierarchy applied to comparing the phosphorylome and the regulome.
C Cheng, E Andrews, KK Yan, M Ung, D Wang, M Gerstein (2015). Genome Biol 16: 63.

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