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Sliding helices. (Top left) View of a bacterial chemotaxis receptor [adapted from (3)] showing the location of the transmembrane helices (red and blue). Note the separation between ligand-binding sites in the periplasmic domain (L) and the secondary binding sites in the cytoplasmic domain (M and S). (Top right) View showing the hypothetical sliding motion of two transmembrane helices. (Bottom) Different views of the close-packing in soluble protein helices.
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